Source: Pharmaceutical Proficient Bio

Stem cells provide a new research direction for many medical problems of human beings. With the frequent reports of clinical research cases of stem cells, the medical community has high hopes for stem cells. In this paper, 43 academicians from the Chinese Academy of Sciences and the Chinese Academy of Engineering spoke highly of stem cells in public in the past six years.

Chen Yihan (Academician of Chinese Academy of Sciences)

Research direction: Clinical work and basic research of cardiovascular diseases

On November 15, 2022, at the 2022 Boao Stem Cell Summit and the founding Conference of China Stem Cell Industry Alliance, Academician Chen Yihan pointed out: "I think stem cell therapy is a sunrise industry with unlimited prospects. Many major diseases may make major breakthroughs through cell therapy. We should carry forward this direction and promote stem cells from research and development to clinical practical application and industrialization."

Zhang Boli (Academician of Chinese Academy of Engineering)

Research direction: Prevention and treatment of cardiovascular and cerebrovascular diseases and modernization of traditional Chinese medicine

On November 14, 2022, Zhang Boli, an academician of the Chinese Academy of Engineering, pointed out in an interview with a reporter of Science and Technology Daily: "In daily life, immunity is a very important weapon to protect the body, as long as the immunity is strong, it can further enhance the ability to resist viruses." A strong immune system requires a stable internal environment and a steady stream of strong repair capabilities. The engines that provide a constant stream of repair and regeneration are stem cells and immune cells."

Li Jinsong (Academician of Chinese Academy of Sciences)

Research interests: Cell reprogramming, stem cells and developmental regulation

On August 17, 2022, at the 24th Shanghai International Symposium on Biotechnology and Medicine, Academician Li Jinsong said: "Spermatozoa-like stem cell-mediated genetic modification integrates the advantages of embryonic stem cell-mediated and germ cell-mediated genetic modification, and can prepare transgenic mice efficiently, accurately and at low cost." Academician Li Jinsong pointed out that the first is at the genetic level, sperm-like stem cells can be used to quickly simulate complex diseases. "Whether it is a single-gene mutation disease, or a double-gene mutation disease, or even a multi-gene mutation disease, precise transformation can be implemented."

Zhan Qimin (Academician of Chinese Academy of Engineering)

Research direction: Tumor molecular biology and translational medicine research

On August 7, 2022, Academician Zhan Qimin said in the "Scientific Celebrity Talk" of Guangxi Association for Science and Technology: "The regenerative ability of stem cells is of great help to the repair and replacement of tissues and organs, and the reconstruction and manufacture of organs. We do a lot of organ transplants. What's the bottleneck of organ transplants? In the absence of donors, stem cells and regenerative medicine can play an important role in this regard. After successfully removing 15 centimeters of a patient's spine, experts at Peking University Third Hospital have used the 3D printed spine to make a good repair on the patient, who is now living normally and even maintaining proper movement."

Chen Yeguang (academician of the Chinese Academy of Sciences)

Research direction: Cell signal transduction and physiological and pathological effects

On May 8, 2022, the People's Daily published a signed article by Chen Ye-guang, an academician of the Chinese Academy of Sciences, entitled "Research and Application of Stem cells -- Safeguarding Human Life and Health." He pointed out: "With the continuous development of life science research, human understanding of stem cells is gradually deepening, and stem-related scientific research results are playing an increasingly important role in disease treatment and regenerative medicine." The application of stem cell technology can not only treat diseases that were difficult to treat in the past, such as leukemia and immune system diseases, but also extend organoid technology to accelerate the development of new drugs, help precision medicine, and even promote regenerative medicine to achieve a leap forward, such as treating Alzheimer's disease and repairing aging organs. We can say that stem cell research and application continue to provide security for people's lives and health."

Zheng Shusen (Academician of Chinese Academy of Engineering)

Research direction: Organ transplantation and hepatobiliary and pancreatic surgery

On April 29, 2022, at the launch meeting of the "14th Five-Year Plan" National Key Research and Development Plan "Stem Cell Research and Organ Repair" of Hangzhou First People's Hospital Affiliated to Zhejiang University School of Medicine, Academician Zheng Shusen said: "Stem cell technology is a cutting-edge technology and has great potential in the field of organ transplantation. Targeted intervention of stem cells is expected to be an effective means to promote liver injury repair and regeneration."

Zhang Zhiyuan (Academician of the Chinese Academy of Engineering)

Research direction: Oral and maxillofacial and head and neck tumors and vascular malformations

On January 21, 2022, at the founding meeting of the Scientific Committee of Stem Cell Therapy of Jinzhong First People's Hospital, Academician Zhang Volunteer said: "Stem cell therapy can be applied to systemic diseases, and its development prospects are getting better and better." In addition, odontogenic stem cells have many advantages, such as strong differentiation and proliferation ability, strong plasticity, long preservation time, low immunogenicity, rich sources and convenient sampling. "The establishment of the Scientific Committee on Stem Cell Therapy is both necessary and timely."

Ju Gong (Academician of Chinese Academy of Sciences)

Research direction: central nervous system tract, spinal cord injury repair

On December 30, 2021, at the 2021 Liaoning Third Medical Frontier and Cell Therapy Conference, Bowing Academician said: "The prevention and treatment of the novel coronavirus epidemic is the focus of social attention, but also the battlefield of scientific researchers and medical personnel, the application of stem cells in critical illness, the scientific research team gave exciting data, human innovation in the conquest of disease, especially at the cellular level of technological innovation, is more exciting."

Zhao Irimin (Academician of Chinese Academy of Engineering)

Research direction: Clinical work and basic research of cardiovascular diseases

On December 20, 2021, "Shaanxi Daily" published "Great Medical Sincerity between Fang Inch - Remembering Zhao Irimin, academician of the Chinese Academy of Engineering and Professor of Stomatology Hospital of the Air Force Military Medical University", quoting Zhao Irimin's words: "The best repair is the human itself, and restoring the natural form and natural function of the human is our ultimate goal." The three 'Rs' - Replacement, Reconstruction and Regeneration - represent the yesterday, today and tomorrow of stomatology, respectively. For a long time, we have been replacing missing teeth and oral tissue with artificial materials. Today, we are reconstructing lost oral tissue in the original form and function. Where is the future of stomatology going? Regenerative medicine, represented by tissue engineering and stem cell technology, gives us new hope."

Li Xiaokun (Academician of Chinese Academy of Engineering)

Research direction: The study of fibroblast growth factor

On November 14, 2021, Academician Xiaokun Li strongly supported Wenzhou to carry out stem cell research at the opening ceremony of Wenzhou Cell Research Center. In his speech, he introduced: "Stem cells are a kind of primitive cell population with self-replicating renewal and multi-differentiation potential, and relevant research has become a global hotspot. At present, the upstream development of the domestic stem cell industry chain is relatively mature, but the midstream stem cell technology and drug research and development, and the downstream stem cell medical application market still stay in the clinical trial or market trial stage, and Wenzhou is still a blank in this field. The development of stem cell industry, Wenzhou has a very good 'soil', I hope that the two sides can work together in the transformation of research results, personnel training and cell product research and development and many other aspects, bold innovation, to carry out continuous, extensive and in-depth cooperation for Wenzhou regenerative medicine health ecology."

Su Guohui (Academician, Chinese Academy of Sciences)

Research interests: Development, plasticity and regeneration of mammalian visual system

At the "Dialogue Brain" academician Forum held in Shanghai on November 19, 2021, Academician Su Guohui said: "Stem cell therapy, as the most advanced treatment in the field of regenerative medicine, has had a significant therapeutic effect in the treatment of knee osteoarthritis, which is bound to promote a subversive revolution in medical and preventive medicine industries." With the continuous improvement and landing of stem cell industrial policies, the future needs to accelerate the research and development of core key technologies, promote the deep integration of science and technology and industry, and strengthen the transformation of scientific and technological achievements.

Wang Guangji (Academician of the Chinese Academy of Engineering)

Research direction: Study on pharmacokinetics of new drugs

On October 20, 2021, at the 2021 China Biotechnology Innovation Conference (the third session), Academician Wang Guangji said: "In the past decade, cellular drugs are triggering a medical revolution. Among them, allogeneic mesenchymal stem cells are the most promising and most likely to become a shelf product of cell therapy, which will make it possible to cure many difficult diseases (such as graft-versus-host disease, systemic lupus erythematosus, Crohn's disease, spinal cord injury, knee osteoarthritis, etc.)."

Wei Yuquan (Academician of Chinese Academy of Sciences)

Research direction: Biological therapy of tumor

On September 25, 2021, Academician Wei Yuquan said at the 2021 Seventh Chengdu International Academic Forum on Precision Medicine: "At present, a number of global biotechnology projects on anti-aging, such as the allogeneic mesymal stem cell project for slowing down aging, have entered clinical trials; Stem cell transplantation for diabetic foot; Human cord blood reshapes hippocampal function in elderly mice to explore research projects such as treating Alzheimer's disease."

Zhou Honghao (Academician of Chinese Academy of Engineering)

Research direction: The research of genetic pharmacology and pharmacogenomics

On September 2, 2021, at the opening ceremony of Hunan Stem Cell and Biomaterials Engineering Research Center, Academician Zhou Honghao said: "Our country is in an important period of development, and the complex international situation requires us to develop in various industries, especially cutting-edge, high-end, critical and breakthrough technologies. Stem cell and pharmaceutical research is one such important area. We are grateful that stem cells will play a very important role in human health in the future. Some prominent chronic diseases, major malignant diseases, completely new diseases, some health problems may benefit from stem cell research translation."

Shi Xuemin (Academician of the Chinese Academy of Engineering)

Research direction: Scientific research of acupuncture

On March 1, 2021, at the "145th Five-Year Plan" development planning seminar held by the National Clinical Medical Research Center of Traditional Chinese Medicine Acupuncture and Moxibustion, Academician Shi Xuemin made a comprehensive deployment for the development of the "145th Five-Year Plan" stage of the national center, he said: "First, acupuncture manipulation quantity is the main research direction of the National Center in the future, based on our current clinical advantages, and the combination of high-level institutions in China to carry out more research on the relationship between acupuncture quantity and effect, and strive to produce more high-quality research results." Second, stem cell research is an initial stage. Currently, the preclinical research on acupuncture combined with stem cells in the treatment of cerebral ischemia is being conducted. In the future, preclinical research on cognitive disorders will be carried out. The third is to respect talents, pay attention to the training of clinical and basic research talents, and give full play to the advantages of various talents."

Chen Kaixian (Academician, Chinese Academy of Sciences)

Research direction: Computer aided drug molecular design

On December 12, 2020, at the second CSCO-Zai New Progress Summit Forum in Clinical Oncology, Academician Chen Kaixian said: "We should attach great importance to the international frontier development direction, including innovative therapies such as gene therapy, immunotherapy, stem cell therapy, and diagnostic products to guide personalized medicine."

Liao Wanqing (Academician of Chinese Academy of Engineering)

Research direction: Prevention and treatment of dermatosis and fungal diseases inside and outside the military

On November 1, 2020, at the first AIE International Symposium on Regenerative Medicine, Academician Liao Wanqing said: "The application of stem cell exosomes in skin clinical will promote a new revolution in dermatological topical preparations. By building a high-level medical research innovation platform now, we believe we will provide more and better solutions for patients in the future."

Wang Fusheng (Academician, Chinese Academy of Sciences)

Research direction: Cellular immunity and antiviral therapy of hepatitis and AIDS

On October 25, 2020, Academician Wang Fusheng said in an interview at the 15th International Genomics Congress: "The most used stem cell therapy is still a kind of mesenchymal stem cell therapy. Mesenchymal stem cell therapy, which mainly plays an immunomodulatory role, can make the abnormal immune response or abnormal inflammatory response in the body cause serious damage to tissues and organs under difficult and dangerous disease conditions. And this stem cell therapy is able to reduce this inflammatory response, it's able to repair this tissue, it's able to promote healing of this tissue, it's also able to promote regeneration of this tissue, so that's a therapeutic effect." In November 2021, the China Disease Cell/Biotherapy Conference was held in the form of an online conference, where Wang Fusheng introduced the efficacy of immune cells and stem cells in hepatitis and COVID-19. He pointed out that cell as a drug is the result of nearly ten years of development, this new technology has a leading, breakthrough, subversive, clinical treatment more timely, more accurate, more intelligent, so that the treatment of major diseases have more and better choices.

Chen Zijiang (Academician, Chinese Academy of Sciences)

Research interests: Reproductive health and birth defects

On September 12, 2020, at the 2020 Stem Cell Clinical Application and Regenerative Medicine Seminar Summit, Academician Chen Zijiang said: "Stem cells have also played a significant role in this year's COVID-19 epidemic. In the field of reproductive medicine, stem cell therapy has been effective in many diseases, such as thin endometrial repair and repeated pregnancy failures.

Yu Jinming (Academician of Chinese Academy of Engineering)

Research direction: The research direction of tumor radiotherapy

On September 12, 2020, at the 2020 Stem Cell Clinical Application and Regenerative Medicine Seminar Summit, Academician Yu Jinming said: "In recent years, life science has become the most rapidly developing and most widely influential scientific field, and the landing of major scientific and technological projects represented by the clinical demonstration of the application of stem cell therapy technology and the construction of industrial bases continues to inject new momentum into the development of stem cell technology." At the same time, the state's policy guidance and financial investment ensure the support of stem cell technology research. The increasing improvement of stem cell research and clinical transformation policies will promote and promote the healthy and rapid development of China's stem cell therapy field. At present, China's stem cell medical industry has a mature industrial chain, from upstream stem cell storage, midstream drug research and development to downstream clinical treatment, there is a relatively complete chain, its development will provide revolutionary technical means for the medical field."

Wang Songling (Academician, Chinese Academy of Sciences)

Research direction: salivary gland diseases, tooth development and regeneration research

On August 22, 2020, at the 2020 China Fortune Forum, Academician Wang Songling said: "After more than ten years of efforts, our research group has used stem cells to treat oral diseases. Where do stem cells come from? Wisdom teeth that come from young people are pulled out, and by the time they're 18 years old they're pulled out and thrown away, they're garbage, but we know there's treasure in there, there's stem cells in there. And baby teeth. Baby teeth are about to fall out, and they have stem cells in them. This is a completely new thing, we've been working on this drug for almost a decade, and we have patents on everything. Through our system, the drug of dental pulp stem cells has gone through an industrial chain, and after it becomes this drug, we can locally inject it to treat periodontitis, and a new drug that can be used in anti-aging and beauty in the future has come out."

Xu Tao (Academician, Chinese Academy of Sciences)

Research interests: islet beta cell function and cell biophysical techniques

On August 8, 2020, at the 2020 International (Guangzhou) Stem Cell and Precision Medicine Industrialization Conference, Academician Xu Tao said: "The effect of stem cells in the treatment of novel coronavirus pneumonia is still good, first of all, its safety has been confirmed, from the effect point of view, there is still a significant improvement in pulmonary fibrosis."

Xu Guanhua (Academician of Chinese Academy of Sciences)

Research direction: Resource remote sensing and geographic information system

On July 14, 2020, on the series of interview program "N Dimensions of Parallel Future" created by Pujiang Innovation Forum, Academician Xu Guanhua said: "In the future, China should grasp four key points to promote scientific and technological innovation: First, we should vigorously cultivate a group of high-level young talents. Second, we will vigorously support the innovation of small and medium-sized technological enterprises. Third, we will continue to increase support for basic research. We will further deepen reform of the scientific and technological system, fully mobilize the enthusiasm and creativity of scientific and technological personnel, and rely on major scientific and technological infrastructure, industrial innovation centers, innovation laboratory clusters and leading scientific and technological innovation enterprises. Lay out and launch a number of basic frontier projects in brain science, artificial intelligence, gene editing, stem cells and regenerative medicine, nanoscience and transformative materials, core mathematics and future computing, life process regulation and design, and strengthen the research and development of basic and applied industrial common technologies. Fourth, we should actively participate in international scientific and technological cooperation."

Wen Yumei (Academician of the Chinese Academy of Engineering)

Research direction: Molecular biology and immunology of hepatitis B virus

On June 10, 2020, Academician Wen Yumei said in the article "Medical Science - Eternal Humanistic Connotation" published by "Science and Technology Guide" Sapphia girl: "The development of modern medicine has two remarkable characteristics: The first is the integration of a large number of new technologies, including the sequencing of the entire human gene, the development of multiple vaccines, the search for disease targets, the development of drugs against targets, new imaging and ultrasound. The development and application of technology, robotic surgery, artificial organs (artificial joints, artificial valves, artificial cardiopulmonary bypass, etc.) as well as immunotherapy and stem cell therapy. These new technologies provide many new treatments for diseases and significantly increase human lifespan, thus also promoting the development of the medical market. Second, with the development of economy, the economy has a broader and deeper impact on the development of medicine. Since the reform and opening up, China has reformed its medical and health services many times and made a series of explorations."

Shi Yigong (Academician of Chinese Academy of Sciences)

Research direction: Structural biology

On June 9, 2020, at the opening ceremony of the 22nd Zhejiang Science and Technology Conference, Academician Shi Yigong said: "With the progress of brain science and structural biology, people are perceiding the mechanism of life at the atomic level, trying to understand how people observe the world in essence. With the maturity of stem cell technology and the development of other biotechnologies, more previously incurable diseases have become curable and manageable."

Chen Runsheng (Academician, Chinese Academy of Sciences)

Research interests: Bioinformatics, non-coding RNA

On June 2, 2020, Academician Chen Runsheng mentioned in the "Academician Time" of Health TV: "The most important thing about stem cells is to replace organ transplantation with cell transplantation, which is revolutionary." Stem cells are undifferentiated cells, which have very good differentiation potential and also have a good function of repairing damaged cells. In general, stem cells will revolutionize humanity and medicine in particular."

Li Lanjuan (Academician of the Chinese Academy of Engineering)

Research direction: Diagnosis and treatment of hepatitis and emerging infectious diseases

On February 3, 2020, CCTV 1 set of "Special Report on the Campaign Situation · Wuhan Live News Room" conducted an interview with Academician Li Lanjuan, member of the high-level group of experts of the National Health Commission. In the interview, Academician Li Lanjuan said that stem cell therapy is very effective after application in Zhejiang, and it has also been used in H7N9, and it has a good effect, so in the rescue of critically ill patients with new coronavirus pneumonia, it will also be applied! On September 24, 2022, the 13th China Biological Industry Conference was held in Wuhan. Academician Li Lanjuan gave an online speech at the conference. She said: "Using new technologies such as artificial liver, stem cells and micro-ecology to treat severe patients can greatly reduce the case fatality rate."

Xia Zhaofan (Academician of the Chinese Academy of Engineering)

Research direction: Clinical diagnosis and treatment, teaching and basic research of burn diseases

On December 18, 2019, at the 115th anniversary of the establishment of the Guangzhou Red Cross Hospital, Academician Xia Zhaofan said in an interview with reporters: "The therapeutic effect of stem cells is currently under observation, and there are two major schools of view, one is that stem cells can wander and gather to the damaged part, and directly transform into the needed and unique cells to participate in repair; The second is that stem cells can secrete proteins and contribute important organelles, such as mitochondria, to help repair locally damaged cells. In animal studies, we have seen that both of these are present, and stem cells have the potential to reduce local scarring and at least allow the skin to heal without deformity or disfigurement caused by scar contracture."

Gu Xiaosong (Academician of Chinese Academy of Engineering)

Research direction: Tissue engineering nerve and nerve regeneration

On November 30, 2019, at the 2019 Healthy China and Health Industry Development Academic Conference, Academician Gu Xiaosong said in an interview with the Meeting Point reporter: "Taking spinal cord injury as an example, tissue engineering technology can regenerate the injured spinal cord through biological materials, stem cells and small molecule drugs, so that patients can gradually restore movement perception." Faced with the rare source of liver donors, Gu Xiaosong said, "We are currently studying the use of cloned stem cells to make liver tissue similar to human imitation, to achieve the normal function of artificial liver, and improve the life of serious patients."

Ji Weizhi (Academician, Chinese Academy of Sciences)

Research interests: Primate reproductive and developmental biology

On November 3, 2019, at the first Biotechnology Innovation Conference opened in Chengdu High-tech Zone, Academician Ji Weizhi pointed out: "Stem cells have brought great hope to human health, and all places should actively fight the beach layout." Ideally, stem cells can differentiate into cells, tissues or organs that we need to repair organs and tissues such as the liver, kidney and heart."

Zhou Qi (Academician of Chinese Academy of Sciences)

Research direction: Cell reprogramming and the future of stem cell research

On September 6, 2019, Academician Zhou Qi said in the CCTV "People" program: "The value of stem cells lies in its scientific nature, stem cells can continue to replicate themselves, it will continue to proliferate, it can also differentiate to various tissues and organs, so its characteristics determine its potential, is to replace, repair those defective organs, and even delay our aging, enhance our health."

Cao Xuetao (Academician of the Chinese Academy of Engineering)

Research interests: Innate immunity and inflammation, tumor immunity

On June 19, 2019, at the closing meeting of the Seventh session of the Standing Committee of the 13th National Committee of the CPPCC, Academician Cao Xuetao explained emerging life science frontier fields such as gene editing, stem cells and tissue regeneration, bioomics, single-cell sequencing technology, synthetic biology, and immunotherapy, and said that these major breakthroughs in biomedical high-tech, It has improved the human ability to understand and interpret life, and promoted the development of biomedical research in the direction of precision, quantification and visualization.

Xiangmei Chen (Academician of Chinese Academy of Engineering)

Research direction: difficult nephropathy, IGA nephropathy, lupus nephritis

On December 1, 2018, at the 2018 Shanghai Annual Academic Meeting on Rare Diseases/Orphan Drugs, Academician Xiangmei Chen said: "The most effective stem cell therapy in the future may be on rare diseases."

Yu Mengsun (Academician of the Chinese Academy of Engineering)

Research direction: Aeromedical and biomedical engineering research

On October 27, 2018, at the 2018 Shenzhen International Biomedical Academician Forum, Academician Yu Mengsun said: "The future health theme of mankind should be to strengthen its own stable state, the process of transforming from health to performence, and the emergence of stem cell therapy has accelerated this process."

Qiao Jie (Academician of the Chinese Academy of Engineering)

Research direction: Clinical and basic research of maternal and reproductive health

On August 10, 2018, in Southeast TV's "China is Saying" program, Academician Qiao Jie said, "We have a case of patients with premature aging, the child is at the age of three or four years old, there are signs of aging, gradually lost hearing, vision can not see clearly, her day is equivalent to our 10 days, and at the age of 10, she is already like a 70-80-year-old old man." Then we used the placental mesenchymal stem cells from the younger brother to treat the older sister for premature aging, and now the older sister is still relatively healthy and alive. She should be one of the longest survivors of this disease in the world."

Yuan Guoyong (Academician of Chinese Academy of Engineering)

Research direction: Research on new pathogens of emerging infectious diseases

On June 12, 2018, Academician Yuen Kwok-yong said in an interview with a reporter from Hong Kong's Ta Kung Pao: "Our researchers extracted a small number of adult stem cells from healthy lung tissue from four lung cancer patients, cultured three-dimensional, self-growing respiratory organoids, which survived for more than a year, and then transformed the three-dimensional organoids into two-dimensional organoids growing on semi-permeable membranes, and carried out viral infection on the top of the two-dimensional organoid epithelial cells." Existing tests for influenza viruses, including past tests with tumor cells that are not representative of human lungs; Human respiratory epithelial cells and human normal lung tissue could not be cultured or the survival time was very short, and it was difficult to maintain the detection criteria. As for the traditional mouse experiment, it is not representative, and the cost of monkey experiment is too high. The organoids cultured from adult stem cells can avoid the above situation, and the research results have been applied for a U.S. patent."

钟南山(中国工程院院士)

Research direction: major respiratory infectious diseases and chronic respiratory diseases

In March 2018, when a reporter asked about the next five-year plan, Academician Zhong Nanshan replied: "One is to use new technologies to solve the small airway problems of COPD and asthma, which is of great help to early diagnosis and early treatment, and the second is to develop a new anti-tumor drug." And one is hoping to do some work on stem cells, which is also being organized right now." In April 2021, at the Xiamen Cell (biological) Therapy Clinical Research Seminar, Zhong Nanshan delivered a speech and made an academic report entitled "Prospects for Cell Therapy", pointing out that in the "13th Five-Year Plan" National Strategic Emerging Industry Development Plan of The State Council, New diagnosis and treatment services such as stem cell and regenerative medicine, tumor immune cell therapy, and CAR T cell therapy are listed as key tasks for development.

Bai Chunli (Academician of Chinese Academy of Sciences)

Research interests: Organic molecular structure, molecular nanostructure

On March 22, 2018, at a symposium held by the Chinese Academy of Sciences to commemorate the 40th anniversary of the Spring of Science, Academician Bai Chunli, then president of the Chinese Academy of Sciences, said: "China's important scientific and technological achievements facing the world's scientific and technological frontiers, such as quantum communication, neutrinos, iron-based superconductivity, Weir fermion, stem cells and regenerative medicine, have reached the forefront of the world."

Liu Yixun (Academician of Chinese Academy of Engineering)

Research direction: Reproductive physiology

On November 22, 2017, Academician Liu Yixun said in an interview with a reporter of Changsha Evening News: "Male infertility patients with non-obstructive azoospermia have no sperm in their bodies and cannot have their own biological children. However, this puzzle is already seeing the light of day: The testis tissue of the patient is taken for in vitro proliferation and differentiation of spermatogonial stem cells. After obtaining the sperm, the sperm is microinjected into the egg through ooplasmic single sperm injection technology to form an embryo, and finally transplanted into the mother for pregnancy. Until the station has achieved complete success in mice and has differentiated sperm in humans, that is to say, in the near future, the sperm cells will be implanted into the human body. It is possible that people with azoospermia will have their own children. In addition, Academician Liu Yixun also revealed a good news: "For female infertility, our researchers isolated mesenchymal stem cells from the patient's menstrual blood, after in vitro culture and expansion, back into the patient's uterus, differentiation into endometrial cells, increase the thickness of the endometrial, making it suitable for embryo transfer." So far, the study has been successful in some patients."

Dai Kerong (Academician of Chinese Academy of Engineering)

Research direction: Orthopaedic clinical and basic research

On November 8, 2017, at the Biological and Life Science Technology and Industry Branch, Academician Dai Ki Rong said: "Regenerative medicine based on tissue engineering has always been the forefront and hot spot of medical research. "Traditional tissue engineering involves three elements: scaffolds, cells (mainly pluripotent stem cells) and growth factors to 'regenerate' new muscles, nerves, bone and other tissues that humans need, and even organs."

Zhao Jizong (Academician of Chinese Academy of Sciences)

Research direction: Clinical and basic research of neurosurgery

On October 26, 2017, at the academic discussion of the 609th Xiangshan Science Conference, Academician Zhao Jizong said: "Rebuilding a microenvironment conducive to nerve regeneration through biomaterials, growth factors and stem cells has become an important strategy for repairing spinal cord injury."

Fu Xiaobing (Academician of Chinese Academy of Engineering)

Research interests: Tissue repair and regeneration after trauma and trauma

On March 30, 2017, the Chinese Journal of Science published an article by Academician Fu Xiaobing, who said: "The induced differentiation function of stem cells can achieve the regeneration of sweat glands in patients." The successful use of this technology is expected to establish a major new technology using stem cells to regenerate sweat glands, and help burn patients avoid the fate of having to blow air conditioning and soak water tanks every day."

Pei Gang (Academician, Chinese Academy of Sciences)

Research interests: Molecular cell biology and signal transduction

On July 17, 2016, at the "SELF Gezhi Lecture" forum, Academician Pei Gang said: "Stem cells are a more ideal material, because stem cells have universal, may be under certain conditions it will change from an all-powerful cell into liver cells, kidney cells, lung cells, heart cells... This in another biological material, or some necessary conditions, it may form an organ, once a functional organ is formed, then its supply to our organs will be no problem, and the health of many people will be better guaranteed." On November 18, 2022, at the founding meeting of the China Stem Cell Industry Alliance, Academician Pei Gang said: "We want to really turn stem cells into products that people like very much, which can not only treat various diseases, but also treat non-disease and aging."